A recent episode of Myopia Movies is about the 2006 film X-Men: The Last Stand. It's the third and last present-day X-Men movie of the early 2000s before the franchise was rebooted with the 1960s-set X-Men: First Class and its historical-fiction sequels.
I was not a participant in the podcast but I did listen. Here are my thoughts:
*Much of the film revolves around how a "cure" for mutation was discovered. Rogue (Anna Paquin), whose life-draining mutant abilities have essentially ruined her life, ends up taking it in order to interact physically with her boyfriend Bobby Drake (Shawn Ashmore) without risking hurting or killing him. However, the ending strongly hints the cure may only be temporary, with a theoretically de-powered Magneto shown able to slightly move a chess-piece. Nic seemed to think this made the whole film pointless, but this has some interesting implications.
If a mutant who wishes to be "normal" has to undergo the procedure repeatedly, this means they're basically living with a chronic illness in terms of expenses. Who paid for Rogue to be "cured" the first time and who will be paying for it if she has to undergo the procedure every few weeks like, say, chemotherapy? Owing to Rogue's age, she was either in high school when her powers kicked in and she ran away from home (high school dropout) or had recently finished (that trip she and her boyfriend were planning in the first film could have been a graduation trip). With that level of education she's going to have a hard time finding a job that could pay for continuous treatment, and that could make her vulnerable to bribery.
(In the comics, Rogue was a originally a villain aligned with Mystique, so her doing increasingly desperate things for money--possibly including betraying the X-Men--because she is absolutely terrified of losing her normal life would make sense. And if she does something so bad Bobby breaks up with her, that emphasizes the tragedy of her situation.)
Also, nobody knows the cure isn't permanent. Imagine her life-draining powers coming back at the absolute worst possible time--say she's making out with or having sex with Bobby and he ends up in a coma like her boyfriend from the first film. Assuming he wakes up, her guilty feelings might lead her to push him away, he might break up with her out of fear, or she might refuse to leave his bedside until he revives and that takes her out of the game when she might well be needed.
*Professor Charles Xavier (Patrick Stewart) transferred his consciousness into the body of a brain-dead man, who awakens at the end of the film. Xavier is in a new body, which potentially means a new actor who'll need to mimic Patrick Stewart's mannerisms and might "speak" telepathically with Stewart's voice, and for the first time in decades is able to walk. This is going to be a very big deal. Also complications--with Xavier legally dead, how is he going to get his money and the school back? There's no real legal precedent for "my body was destroyed but my consciousness is in a new body," so Xavier's enemies in the political realm could take advantage.
*Per politics, the film establishes there's a Department of Mutant Affairs, headed by Beast (Kelsey Grammar). Per one of the Wikis, apparently it is the successor to the villainous William Stryker's anti-mutant paramilitary force. Placing a mutant in charge of a government agency assigned to deal with mutant-related issues reminded me of how the U.S. Bureau of Indian Affairs, previously corrupt as hell and prone to mistreating Native Americans, eventually became largely staffed by Indians.
*With Xavier apparently dead, Storm (Halle Berry) is now in charge of his school and presumably of the X-Men. How will she handle the new responsibilities? And she does have a bit of an attitude problem--something that annoyed me is how she lectured Rogue about how she doesn't need a cure. Storm is so powerful her people back in Africa worshipped her as a weather-controlling goddess (and if you count Age of Apocalypse as something that happened in the past, Apocalypse made her one of his Four Horsemen back in the 1980s), but Rogue literally cannot touch people without hurting or killing them. Storm is blessed beyond imagining, but Rogue's life sucks. Although Beast does tell her how flat-out stupid her attitude is, one wonders if the lesson will stick.
*Wolverine (Hugh Jackman), who was forced to kill love interest Jean Grey (Famke Janssen) after she was totally possessed by an alternate personality called "Phoenix," is going to be a complete mess emotionally. If you've read the X-Men Origins: Wolverine comic, this is not the first time a pretty redhead he's in love with has died because of him. Combine this with my earlier Bobby/Rogue scenario and that's three X-Men who are "out of the game" so to speak.
*Mystique (Rebecca Romjin) had lost her powers and after being callously abandoned by Magneto (Ian McKellen), went over to the government and spilled everything she knew about the Brotherhood. Any members at large after their defeat at Alcatraz, assuming they figure this out, are going to want to KILL her. And without her shape-shifting abilities, she's more vulnerable. Assuming the cure is temporary she might well regain her powers, but until then the Brotherhood might think her an easy target. Key phrase--might think. After all, she's still a skilled martial artist, and I can imagine the overconfident Brotherhood finding that out the hard way. Unless she's in the best witness protection program possible, she might well be safer in prison.
(TVTropes claimed that Mystique was originally supposed to be with Magneto at the end, implying that his "abandonment" of her and her defection to the government were all an elaborate charade. But with the Brotherhood scattered, Magneto's devotees might not get the memo.)
*Magneto has been de-powered, but might be regaining his abilities. He's vulnerable now, and a hunted man. Mystique may well be coming after him--and if her powers return she's once again the perfect spy and assassin--so I can imagine him becoming super-paranoid. And Pyro (Aaron Stanford), if he escaped Alcatraz as well, might challenge the weakened Magneto for leadership of the Brotherhood much like Fabian Cortez attempted to overthrow Magneto in the comics.
*The mutant cure has been weaponized, much like Magneto feared. Having some kind of strike team with plastic guns carrying cure-darts makes sense for dealing with dangerous mutants, which in turn means there's less need for the X-Men. Per my above comment about Xavier and politics, the government might decide now is the time to deal with how he's basically got a private paramilitary force he staffs with the teachers and even students. And an anti-mutant military unit could be misused--"cure" mutants and then kill them.
*If the mutant cure is temporary, captured Brotherhood members jailed in ordinary prisons might suddenly start breaking out. Given how Pyro is the most developed of the villains, that might be a chance for him to return.
Seriously, there are a lot of threads that could have been followed in this one. Rather than the usual Status Quo is God, the filmmakers went total base-breaking with killing off Jean, Cyclops, and (temporarily) Xavier, de-powering (at least temporarily) Rogue, Mystique, and Magneto, making Beast a Cabinet official, and creating something alternatively a miracle or a dangerous anti-mutant weapon. A pity the movie didn't do as well as the others.
